Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

PERIPHERAL NEUROPATHIES

Heterogeneous GBS course requires standardized guidelines

Guillain–Barré syndrome (GBS) outbreaks associated with endemic and epidemic infections have increased in recent decades, and the need for standard treatment guidelines is compelling. A new study presents data from a worldwide prospective observational registry, providing insights into current treatment practices and laying the foundations for future clinical trials.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

References

  1. Wachira, V. K., Peixoto, H. M. & de Oliveira, M. R. Systematic review of factors associated with the development of Guillain-Barré syndrome 2007–2017: what has changed? Trop. Med. Int. Health https://doi.org/10.1111/tmi.13181 (2019).

    Article  PubMed  Google Scholar 

  2. Chevret, S., Hughes, R. A. & Annane, D. Plasma exchange for Guillain-Barré syndrome. Cochrane Database Syst. Rev. 2, CD001798 (2017).

    PubMed  Google Scholar 

  3. Hughes, R. A., Swan, A. V. & van Doorn, P. A. Intravenous immunoglobulin for Guillain-Barré syndrome. Cochrane Database Syst. Rev. 7, CD002063 (2012).

    Google Scholar 

  4. Overell, J. R., Hsieh, S. T., Odaka, M., Yuki, N. & Willison, H. J. Treatment for Fisher syndrome, Bickerstaff’s brainstem encephalitis and related disorders. Cochrane Database Syst. Rev. 1, CD004761 (2007).

    Google Scholar 

  5. Verboon, C. et al. Current treatment practice of Guillain-Barré syndrome. Neurology https://doi.org/10.1212/WNL.0000000000007719 (2019).

    Article  PubMed  Google Scholar 

  6. Hughes, R. A., Brassington, R., Gunn, A. A. & van Doorn, P. A. Corticosteroids for Guillain-Barré syndrome. Cochrane Database Syst. Rev. 10, CD001446 (2016).

    PubMed  Google Scholar 

  7. Walgaard, C. et al. Second IVIg course in Guillain-Barré syndrome patients with poor prognosis (SID-GBS trial): protocol for a double-blind randomized, placebo-controlled clinical trial. J. Peripher. Nerv. Syst. 23, 210–215 (2018).

    Article  CAS  Google Scholar 

  8. Korinthenberg, R., Schessl, J., Kirschner, J. & Mönting, J. S. Intravenously administered immunoglobulin in the treatment of childhood Guillain-Barré syndrome: a randomized trial. Pediatrics 116, 8–14 (2005).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding authors

Correspondence to Kalliopi Pitarokoili or Ralf Gold.

Ethics declarations

Competing interests

K.P. has received speaker honoraria and travel funding from Bayer Schering Pharma, Biogen Idec, Celgene, CSL Behring, Grifols and Novartis. R.G. serves on scientific advisory boards for Bayer Schering Pharma, Biogen Idec, Novartis and Teva Pharmaceutical Industries; has received speaker honoraria from Bayer Schering Pharma, Biogen Idec, Novartis and Teva Pharmaceutical Industries; serves as editor for Therapeutic Advances in Neurological Diseases and is on the editorial boards of Experimental Neurology and the Journal of Neuroimmunology; and receives research support from Bayer Schering Pharma, Biogen Idec, Genzyme, Merck Serono, Novartis and Teva Pharmaceutical Industries, none of which are related to this manuscript.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Pitarokoili, K., Gold, R. Heterogeneous GBS course requires standardized guidelines. Nat Rev Neurol 15, 561–562 (2019). https://doi.org/10.1038/s41582-019-0245-6

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41582-019-0245-6

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing