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Alzheimer disease risk genes: 29 and counting

Nature Reviews Neurology (2019) | Download Citation

The risk of Alzheimer disease is substantially influenced by genetic factors. A new genome-wide association study of more than 600,000 individuals identifies nine novel Alzheimer disease risk genes, raising the total count of independent risk loci to 29.

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L.B. is supported by grants from the Deutsche Forschungsgemeinschaft (DFG), the European Research Council (ERC) and the Cure Alzheimer’s Fund (CAF). R.E.T. is supported by the Cure Alzheimer’s Fund and the JPB Foundation.

Author information


  1. Lübeck Interdisciplinary Platform for Genome Analytics (LIGA), Institutes of Neurogenetics and Cardiogenetics, University of Lübeck, Lübeck, Germany

    • Lars Bertram
  2. Centre for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Oslo, Norway

    • Lars Bertram
  3. McCance Center for Brain Health and Genetics and Aging Research Unit, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, USA

    • Rudolph E. Tanzi


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Competing interests

The authors declare no competing interests.

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Correspondence to Lars Bertram.

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