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ALZHEIMER DISEASE

Nature and implications of sex differences in AD pathology

Nature Reviews Neurology volume 15, pages 6–8 (2019)Cite this article

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A new study has identified key differences between women and men with regard to the nature and burden of Alzheimer disease (AD) pathology in the brain. In addition to highlighting possible sex differences in AD pathophysiology, the findings could have important implications for the diagnosis and management of this condition.

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Fig. 1: Sex differences in Alzheimer disease.

References

  1. Scheltens, P. et al. Alzheimer’s disease. Lancet 388, 505–517 (2016).

    Article  CAS  Google Scholar 

  2. Mielke, M. M., Vemuri, P. & Rocca, W. A. Clinical epidemiology of Alzheimer’s disease: assessing sex and gender differences. Clin. Epidemiol. 6, 37–48 (2014).

    Article  Google Scholar 

  3. Barnes, L. L. et al. Sex differences in the clinical manifestations of Alzheimer disease pathology. Arch. Gen. Psychiatry 62, 685–691 (2005).

    Article  Google Scholar 

  4. Hohman, T. J. et al. Sex-specific association of apolipoprotein E with cerebrospinal fluid levels of tau. JAMA Neurol. 75, 989–998 (2018).

    Article  Google Scholar 

  5. Oveisgharan, S. et al. Sex differences in Alzheimer’s disease and common neuropathologies of aging. Acta Neuropathol. https://doi.org/10.1007/s00401-018-1920-1 (2018).

    Article  PubMed  Google Scholar 

  6. Buckley, R. F. et al. Sex, amyloid, and APOE ε4 and risk of cognitive decline in preclinical Alzheimer’s disease: findings from three well-characterized cohorts. Alzheimers Dement. 14, 1193–1203 (2018).

    Article  Google Scholar 

  7. Altmann, A. et al. Sex modifies the APOE-related risk of developing Alzheimer disease. Ann. Neurol. 75, 563–573 (2014).

    Article  CAS  Google Scholar 

  8. Damoiseaux, J. S. et al. Gender modulates the APOE ε4 effect in healthy older adults: convergent evidence from functional brain connectivity and spinal fluid tau levels. J. Neurosci. 32, 8254–8262 (2012).

    Article  CAS  Google Scholar 

  9. Alzheimer’s Association. 2018 Alzheimer’s disease facts and figures. Alzheimers Dement. 14, 367–429 (2018).

    Article  Google Scholar 

  10. Jack, C. R. et al. Hypothetical model of dynamic biomarkers of the Alzheimer’s pathological cascade. Lancet Neurol. 9, 119–128 (2010).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Neurochemistry Laboratory, Department of Clinical Chemistry, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, Netherlands

    Rosha Babapour Mofrad

  2. Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, Netherlands

    Wiesje M. van der Flier

Authors
  1. Rosha Babapour Mofrad
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  2. Wiesje M. van der Flier
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Correspondence to Wiesje M. van der Flier.

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Babapour Mofrad, R., van der Flier, W.M. Nature and implications of sex differences in AD pathology. Nat Rev Neurol 15, 6–8 (2019). https://doi.org/10.1038/s41582-018-0115-7

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