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NEURODEVELOPMENTAL DISORDERS

New in vivo model provides insights into Down syndrome

Nature Reviews Neurology volume 15, pages 2–3 (2019)Cite this article

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A new study published in Science has shown that human neurons derived from induced pluripotent stem cells (iPSCs) can be implanted into the mouse brain to enable neuronal dynamics to be studied. With this model, researchers were able to demonstrate defects in synaptogenesis and neural network function in iPSC-derived cortical tissue grafts from individuals with Down syndrome.

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  1. Nature Reviews Neurology http://www.nature.com/nrneurol/

    Heather Wood

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  1. Heather Wood
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Correspondence to Heather Wood.

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Wood, H. New in vivo model provides insights into Down syndrome. Nat Rev Neurol 15, 2–3 (2019). https://doi.org/10.1038/s41582-018-0113-9

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  • DOI: https://doi.org/10.1038/s41582-018-0113-9

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