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MOTOR NEURON DISEASE

Amyotrophic lateral sclerosis — a multisystem neurodegenerative disorder

Nature Reviews Neurology volume 15, pages 5–6 (2019)Cite this article

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Amyotrophic lateral sclerosis (ALS) is a progressive motor disorder, and many patients also show non-motor symptoms including executive, behavioural and language dysfunction. A new study demonstrates a robust relationship between progression of these non-motor symptoms and declining motor disease in patients with ALS, providing important insights into mechanisms of ALS pathogenesis.

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Acknowledgements

This work was supported in part by grants from NIH (AG052943, AG054519, AG017586), the Wyncote Foundation and anonymous philanthropic support. The author receives financial support for research projects from Biogen and Avid, support in kind from Avid and Piramal, financial support for consultation from Biogen and Bracco, and financial support as an editor for Neurology. None of these sources of support constitute a conflict of interest with this work.

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  1. Penn Frontotemporal Degeneration Center and Department of Neurology, University of Pennsylvania, Philadelphia, PA, USA

    Murray Grossman

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  1. Murray Grossman
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Correspondence to Murray Grossman.

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Grossman, M. Amyotrophic lateral sclerosis — a multisystem neurodegenerative disorder. Nat Rev Neurol 15, 5–6 (2019). https://doi.org/10.1038/s41582-018-0103-y

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