Evidence mounts for anti-CGRP treatment in cluster headache

During cluster headache attacks, plasma levels of calcitonin gene-related peptide (CGRP) increase, and trigeminal nerve activation leads to pain. A new study shows that CGRP infusion can induce cluster headache attacks in some patients, with important implications for the investigation of CGRP-targeted therapies in cluster headache.

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Correspondence to Massimo Leone.

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The author has received fees from Eli Lilly and TEVA for serving on their advisory boards.

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Leone, M. Evidence mounts for anti-CGRP treatment in cluster headache. Nat Rev Neurol 14, 636–637 (2018). https://doi.org/10.1038/s41582-018-0063-2

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