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HEADACHE

Evidence mounts for anti-CGRP treatment in cluster headache

Nature Reviews Neurology volume 14, pages 636–637 (2018)Cite this article

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During cluster headache attacks, plasma levels of calcitonin gene-related peptide (CGRP) increase, and trigeminal nerve activation leads to pain. A new study shows that CGRP infusion can induce cluster headache attacks in some patients, with important implications for the investigation of CGRP-targeted therapies in cluster headache.

Refers to Vollesen, A. L. et al. Effect of infusion of calcitonin gene-related peptide on cluster headache attacks: a randomized clinical trial. JAMA Neurol. https://doi.org/10.1001/jamaneurol.2018.1675 (2018).

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  1. Department of Neurology, The Foundation of the Carlo Besta Neurological Institute, IRCCS, Milan, Italy

    Massimo Leone

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  1. Massimo Leone
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Correspondence to Massimo Leone.

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The author has received fees from Eli Lilly and TEVA for serving on their advisory boards.

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Leone, M. Evidence mounts for anti-CGRP treatment in cluster headache. Nat Rev Neurol 14, 636–637 (2018). https://doi.org/10.1038/s41582-018-0063-2

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  • DOI: https://doi.org/10.1038/s41582-018-0063-2

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