Following on from a recent European Academy of Neurology guideline on pharmacological treatment of multiple sclerosis (MS), the American Academy of Neurology has issued an updated practice guideline on disease-modifying therapies (DMTs) for MS. The guideline provides 30 general recommendations for initiating, switching and stopping DMTs, and indicates future research directions.
Subscribe to Journal
Get full journal access for 1 year
only $17.42 per issue
All prices are NET prices.
VAT will be added later in the checkout.
Rent or Buy article
Get time limited or full article access on ReadCube.
All prices are NET prices.
Baecher-Allan, C., Kaskow, B. J. & Weiner, H. L. Multiple sclerosis: mechanisms and immunotherapy. Neuron 97, 742–768 (2018).
Larochelle, C., Uphaus, T., Prat, A. & Zipp, F. Secondary progression in multiple sclerosis: neuronal exhaustion or distinct pathology? Trends Neurosci. 39, 325–339 (2016).
Rae-Grant, A. et al. Practice guideline recommendations summary: disease-modifying therapies for adults with multiple sclerosis: report of the Guideline Development, Dissemination, and Implementation Subcommittee of the American Academy of Neurology. Neurology 90, 777–788 (2018).
Montalban, X. et al. ECTRIMS/EAN guideline on the pharmacological treatment of people with multiple sclerosis. Eur. J. Neurol. 25, 215–237 (2018).
D’Amico, E., Zanghi, A., Leone, C., Tumani, H. & Patti, F. Treatment-related progressive multifocal leukoencephalopathy in multiple sclerosis: a comprehensive review of current evidence and future needs. Drug Saf. 39, 1163–1174 (2016).
Berger, J. R. et al. Progressive multifocal leukoencephalopathy after fingolimod treatment. Neurology 90, e1815–e1821 (2018).
Gieselbach, R. J. et al. Progressive multifocal leukoencephalopathy in patients treated with fumaric acid esters: a review of 19 cases. J. Neurol. 264, 1155–1164 (2017).
Kalincik, T. et al. Towards personalized therapy for multiple sclerosis: prediction of individual treatment response. Brain 140, 2426–2443 (2017).
Disanto, G. et al. Serum Neurofilament light: a biomarker of neuronal damage in multiple sclerosis. Ann. Neurol. 81, 857–870 (2017).
Siller, N. et al. Serum neurofilament light chain is a biomarker of acute and chronic neuronal damage in early multiple sclerosis. Mult. Scler. https://doi.org/10.1177/1352458518765666 (2018).
The authors thank C. Ernest for proofreading the manuscript. The authors’ work is funded by the German Research Foundation (DFG) and the German Federal Ministry of Education and Research (BMBF).
S.B. has recently received consultation funds from Merck Serono, Novartis, Sanofi-Aventis and Roche. F.Z. has recently received research grants from Genzyme and Merck Serono, as well as consultation funds from Roche, Merck Serono, Novartis, Sanofi-Aventis, Celgene and Octapharma.
About this article
Cite this article
Bittner, S., Zipp, F. AAN unveils new guidelines for MS disease-modifying therapy. Nat Rev Neurol 14, 384–386 (2018). https://doi.org/10.1038/s41582-018-0026-7
Nature Reviews Neurology (2019)