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Healthy ageing and the kidney — lessons from centenarians

Nature Reviews Nephrology volume 20, pages 558–559 (2024)Cite this article

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Centenarians — who are a putative model of healthy longevity — often have a low risk of cardiovascular disease, despite an age-associated decline in kidney function. An understanding of the molecular and cellular underpinnings of health kidney ageing in centenarians may provide clues for the prevention or alleviation of the burden of kidney disease in older populations.

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Fig. 1: Proposed extent of structural and functional changes that occur the kidney in individuals with chronic kidney disease, in those who undergo normal ageing and in centenarians.

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Authors and Affiliations

  1. Center for Supercentenarian Medical Resaerch, Keio University School of Medicine, Tokyo, Japan

    Yasumichi Arai

  2. Department of Nephrology, Graduate School of Medicine, Kyoto University, Kyoto, Japan

    Motoko Yanagita

  3. Institute for the Advanced Study of Human Biology (ASHBi), Kyoto University, Kyoto, Japan

    Motoko Yanagita

Authors
  1. Yasumichi Arai
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  2. Motoko Yanagita
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Correspondence to Yasumichi Arai.

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Competing interests

M.Y. has received research grants from Mitsubishi Tanabe Pharma and Boehringer Ingelheim. Y.A. declares no competing interests.

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Arai, Y., Yanagita, M. Healthy ageing and the kidney — lessons from centenarians. Nat Rev Nephrol 20, 558–559 (2024). https://doi.org/10.1038/s41581-024-00860-y

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