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Ageing

Not every organ ticks the same

A new study describes the development of proteomics-based ageing clocks that calculate the biological age of specific organs and define features of extreme ageing associated with age-related diseases. Their findings support the notion that plasma proteins can be used to monitor the ageing rates of specific organs and disease progression.

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Fig. 1: Plasma proteomes from three healthy cohorts and two cohorts with Alzheimer disease (AD) were used to model organ-specific ageing and calculate age gaps.

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Acknowledgements

The authors thank Carl Grabitz, Hannover Medical School, for creating the original artwork.

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Correspondence to Anette Melk.

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The authors declare no competing interests.

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Talbi, K., Melk, A. Not every organ ticks the same. Nat Rev Nephrol 20, 431–432 (2024). https://doi.org/10.1038/s41581-024-00842-0

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