A new study used metabolic tracing of the three main carbon sources (glucose, glutamine and lipids) on cultured slices of mouse kidneys to identify the dynamic metabolic changes that occur after injury in different segments of the kidney tubule at the single-cell level.
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Acknowledgements
The author thanks L. Cassina and M. E. Steidl for feedback on the manuscript before submission. A.B. is supported by the Italian Ministry of Health (RF-2018-12368254; RF-2016-02361267), the Italian association of patients with PKD (AIRP), the PKD Foundation (218G18), the European Community (H-2020-MSCA-ITN-2019#SCiLS) and the Italian Association for Research on Cancer (AIRC, IG2019-23513).
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Boletta, A. Spatial metabolic tracing in the kidney — the future is now. Nat Rev Nephrol 19, 5–6 (2023). https://doi.org/10.1038/s41581-022-00644-2
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DOI: https://doi.org/10.1038/s41581-022-00644-2
