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Salt substitution: opportunities and challenges for nephrology

Salt substitution — the partial replacement of sodium with potassium in table salt — is emerging as a powerful public health strategy to reduce hypertension and related diseases. Here, we explore whether salt substitution is suitable for people with kidney disease by weighing the potential cardiorenal benefits against the risk of hyperkalaemia.

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Fig. 1: Potential benefits and risks of salt substitution in people with CKD.


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E.J.H.’s work is supported by the Dutch Kidney Foundation (grant 21OK+13).

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Correspondence to Ewout J. Hoorn.

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Hoorn, E.J., Marklund, M. & Wu, J.H.Y. Salt substitution: opportunities and challenges for nephrology. Nat Rev Nephrol 18, 539–540 (2022).

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