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DIABETIC KIDNEY DISEASE

mTORC1 under the control of CB1R

Nature Reviews Nephrology volume 18, page 345 (2022)Cite this article

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Hyperglycaemia-induced metabolic dysregulation is one of the main drivers of diabetic kidney disease (DKD). Now, Joseph Tam and colleagues report that cannabinoid 1 receptor (CB1R) can regulate the activity of mammalian target of rapamycin complex 1 (mTORC1) in proximal tubule cells (PTCs), with opposing effects depending on glucose levels.

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References

Original article

  • Hinden, L. et al. Opposite physiological and pathological mTORC1-mediated roles of the CB1 receptor in regulating renal tubular function. Nat. Commun. 13, 1783 (2022)

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  1. Nature Reviews Nephrology http://www.nature.com/nrneph

    Monica Wang

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  1. Monica Wang
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Correspondence to Monica Wang.

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Wang, M. mTORC1 under the control of CB1R. Nat Rev Nephrol 18, 345 (2022). https://doi.org/10.1038/s41581-022-00582-z

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  • DOI: https://doi.org/10.1038/s41581-022-00582-z

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