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GLOMERULONEPHRITIS

A recombinant fusion protein clears IgA deposits

Nature Reviews Nephrology volume 18, page 273 (2022)Cite this article

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A new study suggests that a recombinant fusion protein could be a promising candidate therapy for IgA nephropathy. Xie et al. fused the N terminus of an IgA protease from the commensal bacteria Clostridium ramosum with the Fc segment of human IgG1 to construct a chimeric protease with an extended half-life in vivo. In mice injected with human IgA and in a humanized mouse model of IgA nephropathy, this protease, termed Fc-AK183, cleared IgA from the circulation and cleared deposits of IgA and associated complement C3 from the glomeruli.

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  1. Nature Reviews Nephrology http://www.nature.com/nrneph

    Ellen F. Carney

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  1. Ellen F. Carney
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Correspondence to Ellen F. Carney.

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Carney, E.F. A recombinant fusion protein clears IgA deposits. Nat Rev Nephrol 18, 273 (2022). https://doi.org/10.1038/s41581-022-00568-x

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  • DOI: https://doi.org/10.1038/s41581-022-00568-x

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