Decades of research have revealed that nephron number is a crucial determinant of kidney health. However, a lack of appropriate tools has limited these studies to ex vivo analyses. For the first time, techniques are emerging that might enable the use of functional nephron number as a biomarker in living humans.
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K.M.B. and J.R.C. own Sindri Technologies, LLC. K.M.B. owns Nephrodiagnostics, LLC. K.M.B. and E.J.B. own XN Biotechnologies, LLC. K.M.B. has a sponsored research agreement with Johnson & Johnson Corp. J.R.C. is a consultant for Medtronics.
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Bennett, K.M., Baldelomar, E.J. & Charlton, J.R. Delivering on the potential of measuring nephron number in the clinic. Nat Rev Nephrol 18, 271–272 (2022). https://doi.org/10.1038/s41581-022-00560-5