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SGLT2 inhibitors may prevent diabetes

Dapagliflozin reduces the risk of new-onset diabetes mellitus, according to results from a pre-specified pooled analysis of the DAPA-CKD and DAPA-HF trials. The study adds to the growing list of sodium–glucose co-transporter 2 inhibitor benefits and raises the possibility of an expanded target patient population.

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Fig. 1: Effect of SGLT2 inhibitors on the risk of a new-onset diagnosis of diabetes in people with prediabetes.


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D.V.O. receives support through an Australian Government Research Training Program Scholarship and an NHMRC Clinical Trials Centre Postgraduate Research Scholarship. M.J.J. is supported by a Medical Research Future Fund Next Generation Clinical Researchers Program Career Development Fellowship.

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Correspondence to Meg J. Jardine.

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M.J.J. is responsible for research projects that have received funding from CSL, Dimerix, Eli Lilly and MSD and has received advisory, steering committee and/or speaker fees from AstraZeneca, Bayer, Boehringer Ingelheim, Chinook, CSL, Janssen, Merck, MSD, Roche and Vifor (all consultancy fees or honoraria are paid to her institution). D.V.O. declares no competing interests.

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O’Hara, D.V., Jardine, M.J. SGLT2 inhibitors may prevent diabetes. Nat Rev Nephrol 18, 203–204 (2022).

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