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STRUCTURAL BIOLOGY

Cryo-EM structure of AVP–V2 receptor complex

Nature Reviews Nephrology volume 17, page 511 (2021)Cite this article

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The antidiuretic hormone arginine–vasopressin (AVP) forms a signalling complex with the vasopressin V2 receptor (V2R) and the Gs protein to promote water reabsorption in the kidney. Now, Bous and colleagues report the cryo-electron microscopy (cryo-EM) structure of the AVP–V2R–Gs complex. Analysis of two ternary complex structures revealed distinct agonist and G protein binding modes, and provided insights into the mechanisms by which specific V2R mutations might affect V2R activity and Gs coupling, resulting in distinct X-linked genetic diseases: congenital nephrogenic diabetes insipidus and nephrogenic syndrome of inappropriate antidiuresis.

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Original article

  • Bous, J. et al. Cryo-electron microscopy structure of the antidiuretic hormone arginine-vasopressin V2 receptor signaling complex. Sci. Adv. 7, eabg5628 (2021)

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  1. Nature Reviews Nephrology http://www.nature.com/nrneph

    Susan Allison

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  1. Susan Allison
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Correspondence to Susan Allison.

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Allison, S. Cryo-EM structure of AVP–V2 receptor complex. Nat Rev Nephrol 17, 511 (2021). https://doi.org/10.1038/s41581-021-00456-w

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  • DOI: https://doi.org/10.1038/s41581-021-00456-w

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