Proper glomerular basement membrane (GBM) structure and function are required for appropriate glomerular filtration and abnormalities in the α3α4α5 (α345) network of collagen IV — a GBM component — can lead to disease. New insights into the mechanisms underlying α345 hexamer assembly and function from genetic and structural data identify possible targets for therapeutic modulation.
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Tryggvason, K. Complex genetics of Alport and Goodpasture syndromes. Nat Rev Nephrol 17, 635–636 (2021). https://doi.org/10.1038/s41581-021-00451-1
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DOI: https://doi.org/10.1038/s41581-021-00451-1