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Complex genetics of Alport and Goodpasture syndromes

Proper glomerular basement membrane (GBM) structure and function are required for appropriate glomerular filtration and abnormalities in the α3α4α5 (α345) network of collagen IV — a GBM component — can lead to disease. New insights into the mechanisms underlying α345 hexamer assembly and function from genetic and structural data identify possible targets for therapeutic modulation.

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Fig. 1: Assembly of the collagen IV α3α4α5 network.


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Correspondence to Karl Tryggvason.

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Tryggvason, K. Complex genetics of Alport and Goodpasture syndromes. Nat Rev Nephrol (2021).

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