SARS-CoV-2 gains entry to host cells via angiotensin-converting enzyme 2 (ACE2). Now, research demonstrates a role for a soluble form of ACE2 (sACE2) and vasopressin in mediating SARS-CoV-2 entry into susceptible cells. Using kidney HK-2 cells, which are highly susceptible to SARS-CoV-2 infection, Yeung et al. show that interaction of the SARS-CoV-2 spike protein with sACE2 or with a complex of sACE2 plus vasopressin mediates receptor-mediated endocytosis of the virus via type 1 angiotensin and vasopressin V1b receptors, respectively.
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Yeung, M. L. et al. Soluble ACE2-mediated cell entry of SARS-CoV-2 via interaction with proteins related to the renin–angiotensin system. Cell https://doi.org/10.1016/j.cell.2021.02.053 (2021)
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Allison, S. Soluble ACE2 in SARS-CoV-2 infection. Nat Rev Nephrol 17, 297 (2021). https://doi.org/10.1038/s41581-021-00422-6
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DOI: https://doi.org/10.1038/s41581-021-00422-6
