Using the exposome to address gene–environment interactions in kidney disease

New exposome-based approaches permit omic-scale characterization of the non-genetic contributors to kidney disease. High-resolution mass spectrometry analysis of plasma and urine samples captures a wide range of exogenous and endogenous metabolites that can be used in combination with genetic risk factors to identify new biomarkers of exposure and therapeutic approaches.

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Correspondence to Gary W. Miller.

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Dupre, T.V., Schnellmann, R.G. & Miller, G.W. Using the exposome to address gene–environment interactions in kidney disease. Nat Rev Nephrol 16, 621–622 (2020).

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