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Innovations in approaches to remove uraemic toxins

Nature Reviews Nephrology volume 16, pages 552–553 (2020)Cite this article

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Kidney failure is associated with the retention and subsequent accumulation of uraemic toxins, which have detrimental effects on various physiological processes. The removal of these toxins by current dialysis modalities is inadequate, highlighting the need for innovative approaches to enhance their clearance and/or suppress their generation to improve outcomes for patients with kidney disease.

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Authors and Affiliations

  1. Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht, The Netherlands

    Rosalinde Masereeuw

  2. Department of Nephrology and Hypertension, University Medical Center Utrecht, Utrecht, The Netherlands

    Marianne C. Verhaar

Authors
  1. Rosalinde Masereeuw
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  2. Marianne C. Verhaar
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Corresponding author

Correspondence to Rosalinde Masereeuw.

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Competing interests

R.M. has received a grant from Gambro Dialysatoren GmbH (Baxter) for collaborative research and is a member of the ESAO/ERA-EDTA endorsed Work Group EUTox. M.C.V. declares no competing interests.

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Related links

European Uremic Toxin Work Group: http://www.uremic-toxins.org/

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Masereeuw, R., Verhaar, M.C. Innovations in approaches to remove uraemic toxins. Nat Rev Nephrol 16, 552–553 (2020). https://doi.org/10.1038/s41581-020-0299-0

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