Innovations in dialysis membranes for improved kidney replacement therapy

Haemodialysis is a life-saving therapy. However, in comparison with the healthy kidney, it removes only a small fraction of the uraemic toxins produced, does not function continuously and cannot replicate biological kidney functions. Innovations in membrane design hold promise to overcome these limitations with potential to improve patient outcomes.

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References

  1. 1.

    Ronco, C. & Clark, W. R. Haemodialysis membranes. Nat. Rev. Nephrol. 14, 394–410 (2018).

    CAS  Article  Google Scholar 

  2. 2.

    Legallais, C. et al. Bioengineering organs for blood detoxification. Adv. Healthc. Mater. 7, e1800430 (2018).

    Article  Google Scholar 

  3. 3.

    Florens, N. et al. Using binding competitors of albumin to promote the removal of protein-bound uremic toxins in hemodialysis: hope or pipe dream? Biochimie 144, 1–8 (2018).

    CAS  Article  Google Scholar 

  4. 4.

    Storr, M. & Ward, R. A. Membrane innovation: closer to native kidneys. Nephrol. Dial. Transplant. 33 (Suppl. 3), iii22–iii27 (2018).

    CAS  Article  Google Scholar 

  5. 5.

    Feinberg, B. J. et al. Silicon nanoporous membranes as a rigorous platform for validation of biomolecular transport models. J. Memb. Sci. 536, 44–51 (2017).

    CAS  Article  Google Scholar 

  6. 6.

    Geremia, I. et al. In vitro assessment of mixed matrix hemodialysis membrane for achieving endotoxin-free dialysate combined with high removal of uremic toxins from human plasma. Acta Biomaterialia 90, 100–111 (2019).

    CAS  Article  Google Scholar 

  7. 7.

    ter Beek, O. E. M. et al. Hollow fiber membranes for long-term hemodialysis based on polyethersulfone-SlipSkin™ polymer blends. J. Memb. Sci. 604, 118068 (2020).

    Article  Google Scholar 

  8. 8.

    Dukhin, S. S. et al. Outside-in hemofiltration for prolonged operation without clogging. J. Memb. Sci. 464, 173–178 (2014).

    CAS  Article  Google Scholar 

  9. 9.

    Chevtchik, N. V. et al. Upscaling of a living membrane for bioartificial kidney device. Eur. J. Pharmacol. 790, 28–35 (2016).

    CAS  Article  Google Scholar 

  10. 10.

    Fissell, W. & Roy, S. The implantable artificial kidney. Semin. Dial. 22, 665–670 (2009).

    Article  Google Scholar 

Download references

Acknowledgements

The authors acknowledge the financial support of the EUTox working group of the European society of European Society for artificial organs, and The Stitching Life Sciences Health – TKI (Grant no. LSHM16059-SGF (NOVAMEM).

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Correspondence to Dimitrios Stamatialis.

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The authors declare no competing interests.

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Kidney Health Initiative: https://khi.asn-online.org

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Geremia, I., Stamatialis, D. Innovations in dialysis membranes for improved kidney replacement therapy. Nat Rev Nephrol 16, 550–551 (2020). https://doi.org/10.1038/s41581-020-0293-6

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