Haemodialysis is a life-saving therapy. However, in comparison with the healthy kidney, it removes only a small fraction of the uraemic toxins produced, does not function continuously and cannot replicate biological kidney functions. Innovations in membrane design hold promise to overcome these limitations with potential to improve patient outcomes.
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References
Ronco, C. & Clark, W. R. Haemodialysis membranes. Nat. Rev. Nephrol. 14, 394–410 (2018).
Legallais, C. et al. Bioengineering organs for blood detoxification. Adv. Healthc. Mater. 7, e1800430 (2018).
Florens, N. et al. Using binding competitors of albumin to promote the removal of protein-bound uremic toxins in hemodialysis: hope or pipe dream? Biochimie 144, 1–8 (2018).
Storr, M. & Ward, R. A. Membrane innovation: closer to native kidneys. Nephrol. Dial. Transplant. 33 (Suppl. 3), iii22–iii27 (2018).
Feinberg, B. J. et al. Silicon nanoporous membranes as a rigorous platform for validation of biomolecular transport models. J. Memb. Sci. 536, 44–51 (2017).
Geremia, I. et al. In vitro assessment of mixed matrix hemodialysis membrane for achieving endotoxin-free dialysate combined with high removal of uremic toxins from human plasma. Acta Biomaterialia 90, 100–111 (2019).
ter Beek, O. E. M. et al. Hollow fiber membranes for long-term hemodialysis based on polyethersulfone-SlipSkin™ polymer blends. J. Memb. Sci. 604, 118068 (2020).
Dukhin, S. S. et al. Outside-in hemofiltration for prolonged operation without clogging. J. Memb. Sci. 464, 173–178 (2014).
Chevtchik, N. V. et al. Upscaling of a living membrane for bioartificial kidney device. Eur. J. Pharmacol. 790, 28–35 (2016).
Fissell, W. & Roy, S. The implantable artificial kidney. Semin. Dial. 22, 665–670 (2009).
Acknowledgements
The authors acknowledge the financial support of the EUTox working group of the European society of European Society for artificial organs, and The Stitching Life Sciences Health – TKI (Grant no. LSHM16059-SGF (NOVAMEM).
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Kidney Health Initiative: https://khi.asn-online.org
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Geremia, I., Stamatialis, D. Innovations in dialysis membranes for improved kidney replacement therapy. Nat Rev Nephrol 16, 550–551 (2020). https://doi.org/10.1038/s41581-020-0293-6
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DOI: https://doi.org/10.1038/s41581-020-0293-6
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