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One step closer to alleviating uraemic pruritus

The KALM-1 randomized double-blind placebo-controlled phase III trial showed that intravenous difelikefalin, a selective κ-opioid receptor agonist, significantly reduces itch intensity in haemodialysis patients with uraemic pruritus. However, 49% of difelikefalin-treated patients showed no improvement. In light of the increasing number of patients with end-stage renal disease, additional treatments are sorely needed.

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Correspondence to Elke Weisshaar.

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Competing interests

E.W. is principal investigator in clinical trials sponsored by Trevi Therapeutics and Menlo Therapeutics. R.F.O. declares no competing interests.

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Weisshaar, E., Ofenloch, R.F. One step closer to alleviating uraemic pruritus. Nat Rev Nephrol 16, 189–190 (2020).

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