In recent years, the molecular view of clear cell renal cell carcinoma (ccRCC) has been based primarily on gene transcription data with limited information on protein features. A new study led by the Clinical Proteomic Tumor Analysis Consortium now offers a comprehensive view of the ccRCC proteome.
This is a preview of subscription content, access via your institution
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on SpringerLink
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Clark, D. et al. Integrated proteogenomic characterization of clear cell renal cell carcinoma. Cell 179, 964–983 (2019).
Akbani, R. et al. A pan-cancer proteomic perspective on The Cancer Genome Atlas. Nat. Commun. 5, 3887 (2014).
Zhang, Y. et al. A pan-cancer proteogenomic atlas of PI3K/AKT/mTOR pathway alterations. Cancer Cell 31, 820–832 (2017).
Chen, F. et al. Multilevel genomics-based taxonomy of renal cell carcinoma. Cell Rep. 14, 2476–2489 (2016).
The Cancer Genome Atlas Research Network. Comprehensive molecular characterization of papillary renal cell carcinoma. N. Engl. J. Med. 374, 135–145 (2015).
The Cancer Genome Atlas Research Network. Comprehensive molecular characterization of clear cell renal cell carcinoma. Nature 499, 43–49 (2013).
Cancer Genome Atlas Research Network et al. The Cancer Genome Atlas pan-cancer analysis project. Nat. Genet. 45, 1113–1120 (2013).
Edwards, N. et al. The CPTAC data portal: a resource for cancer proteomics research. J. Proteome. Res. 14, 2707–2713 (2015).
Chandrashekar, D. et al. UALCAN: a portal for facilitating tumor subgroup gene expression and survival analyses. Neoplasia 19, 649–658 (2017).
Davis, C. et al. The somatic genomic landscape of chromophobe renal cell carcinoma. Cancer Cell 26, 319–330 (2014).
Acknowledgements
This work was supported in part by National Institutes of Health (NIH) grant P30CA125123.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The author declares no competing interests.
Rights and permissions
About this article
Cite this article
Creighton, C.J. Proteomic signatures of clear cell renal cell carcinoma. Nat Rev Nephrol 16, 133–134 (2020). https://doi.org/10.1038/s41581-019-0233-5
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41581-019-0233-5