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DIABETIC KIDNEY DISEASE

Type IV collagen and diabetic kidney disease

A new genome-wide association study of patients with type 1 diabetes mellitus reveals novel loci that are associated with the development of diabetic kidney disease. The most significant of these loci encodes the α3 chain of type IV collagen, which is an important component of the glomerular basement membrane.

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Fig. 1: A COL4A3 variant is associated with the risk of diabetic kidney disease.

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Correspondence to Jeffrey H. Miner.

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J.H.M. acknowledges collagen IV and diabetes-related grants from the NIH/NIDDK (R01DK078314, P30DK020579, and Diabetic Complications Consortium grants U24DK076169 and U24DK115255) and a sponsored research agreement from Reneo Pharmaceuticals.

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Miner, J.H. Type IV collagen and diabetic kidney disease. Nat Rev Nephrol 16, 3–4 (2020). https://doi.org/10.1038/s41581-019-0229-1

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