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Type IV collagen and diabetic kidney disease

A new genome-wide association study of patients with type 1 diabetes mellitus reveals novel loci that are associated with the development of diabetic kidney disease. The most significant of these loci encodes the α3 chain of type IV collagen, which is an important component of the glomerular basement membrane.

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Fig. 1: A COL4A3 variant is associated with the risk of diabetic kidney disease.


  1. 1.

    Regele, F. et al. Genome-wide studies to identify risk factors for kidney disease with a focus on patients with diabetes. Nephrol. Dial. Transplant. 30 (Suppl. 4), iv26–iv34 (2015).

    CAS  Article  Google Scholar 

  2. 2.

    Salem, R. M. et al. Genome-wide association study of diabetic kidney disease highlights biology involved in glomerular basement membrane collagen. J. Am. Soc. Nephrol. 30, 2000–2016 (2019).

    Article  Google Scholar 

  3. 3.

    Suh, J. H. & Miner, J. H. The glomerular basement membrane as a barrier to albumin. Nat. Rev. Nephrol. 9, 470–477 (2013).

    CAS  Article  Google Scholar 

  4. 4.

    Fioretto, P. & Mauer, M. Histopathology of diabetic nephropathy. Semin. Nephrol. 27, 195–207 (2007).

    Article  Google Scholar 

  5. 5.

    Miner, J. H. Pathology versus molecular genetics: (re)defining the spectrum of Alport syndrome. Kidney Int. 86, 1081–1083 (2014).

    CAS  Article  Google Scholar 

  6. 6.

    Kashtan, C. E. et al. Alport syndrome: a unified classification of genetic disorders of collagen IV alpha345: a position paper of the Alport Syndrome Classification Working Group. Kidney Int. 93, 1045–1051 (2018).

    Article  Google Scholar 

  7. 7.

    Savige, J. et al. Thin basement membrane nephropathy. Kidney Int. 64, 1169–1178 (2003).

    Article  Google Scholar 

  8. 8.

    Gross, O. et al. DDR1-deficient mice show localized subepithelial GBM thickening with focal loss of slit diaphragms and proteinuria. Kidney Int. 66, 102–111 (2004).

    CAS  Article  Google Scholar 

  9. 9.

    Richter, H. et al. DNA-encoded library-derived DDR1 inhibitor prevents fibrosis and renal function loss in a genetic mouse model of Alport syndrome. ACS Chem. Biol. 14, 37–49 (2019).

    CAS  Article  Google Scholar 

  10. 10.

    Gross, O. et al. Loss of collagen-receptor DDR1 delays renal fibrosis in hereditary type IV collagen disease. Matrix Biol. 29, 346–356 (2010).

    CAS  Article  Google Scholar 

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Correspondence to Jeffrey H. Miner.

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Competing interests

J.H.M. acknowledges collagen IV and diabetes-related grants from the NIH/NIDDK (R01DK078314, P30DK020579, and Diabetic Complications Consortium grants U24DK076169 and U24DK115255) and a sponsored research agreement from Reneo Pharmaceuticals.

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Miner, J.H. Type IV collagen and diabetic kidney disease. Nat Rev Nephrol 16, 3–4 (2020).

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