Histocompatibility: minor differences have a major impact

The clinical relevance of minor histocompatibility antigens in transplantation is disputed. High-throughput approaches are now being used to investigate the role of genome-wide genetic incompatibility in transplant outcomes. A recent study reports that donor and recipient mismatch at the LIMS1 locus is associated with an increased risk of acute rejection.

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Fig. 1: Hypothetical mechanisms by which the LIMS1 collision genotype might lead to acute cellular rejection.


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We acknowledge the generous help of A. Heinzel (Medical University of Vienna, Austria) in preparing this article. This work was supported by the Vienna Science and Technology Fund WWTF (grant # LS16-019 and # LS18-031) and the Österreichisch Nationalbank (grant # 17289).

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Correspondence to Rainer Oberbauer.

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Reindl-Schwaighofer, R., Oberbauer, R. Histocompatibility: minor differences have a major impact. Nat Rev Nephrol 15, 529–530 (2019).

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