Considerations for SGLT2 inhibitor use in post-transplantation diabetes

Sodium–glucose cotransporter 2 inhibitors (SGLT2i) have been recommended for the treatment of patients with type 2 diabetes mellitus and cardiovascular disease, heart failure or chronic kidney disease. Findings from recent efficacy and safety trials of empagliflozin in kidney transplant recipients with post-transplantation diabetes are timely, given the elevated cardiovascular risk associated with solid organ transplantation.

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The Empa-Renal Tx study from Oslo, Norway, was initiated and funded by the investigators and supported by grants from the South-Eastern Norway Regional Health Authority, the Norwegian Diabetes Association and Oslo Diabetes Research Centre. This study was supported by an unrestricted grant from Boehringer Ingelheim, Norway.

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Corresponding authors

Correspondence to Manfred Hecking or Trond Jenssen.

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Competing interests

T.J. has received lecture honoraria from Boehringer Ingelheim, AstraZeneca and Merck Sharp & Dohme. M.H. declares no competing interests.

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Hecking, M., Jenssen, T. Considerations for SGLT2 inhibitor use in post-transplantation diabetes. Nat Rev Nephrol 15, 525–526 (2019).

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