Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

END-STAGE RENAL DISEASE

Cardiovascular disease in young adults with incident ESRD

Nature Reviews Nephrology volume 15, pages 390–391 (2019)Cite this article

Subjects

Cardiovascular disease (CVD) is a leading cause of death in young adults with incident end-stage renal disease (ESRD). Unlike children with ESRD, young adults with incident ESRD have high prevalence of diabetes, coronary artery disease and heart failure. These cardiovascular risk factors are associated with increased CVD-related hospitalizations and mortality in young adults.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: Cardiovascular disease (CVD) burden from childhood to young adulthood.

References

  1. Levey, A. S. et al. Controlling the epidemic of cardiovascular disease in chronic renal disease: What do we know? What do we need to learn? Where do we go from here? National Kidney Foundation Task Force on Cardiovascular Disease. Am. J. Kidney Dis. 32, 853–906 (1998).

    Article  CAS  Google Scholar 

  2. Parekh, R. S. et al. Cardiovascular mortality in children and young adults with end-stage kidney disease. J. Pediatr. 141, 191–197 (2002).

    Article  CAS  Google Scholar 

  3. McDonald, S. P. & Craig, J. C. Long-term survival of children with end-stage renal disease. N. Engl. J. Med. 350, 2654–2662 (2004).

    Article  CAS  Google Scholar 

  4. Mitsnefes, M. M. et al. Mortality risk among children initially treated with dialysis for end-stage kidney disease, 1990–2010. JAMA 309, 1921–1929 (2013).

    Article  CAS  Google Scholar 

  5. Modi, Z. J. et al. Risk of cardiovascular disease and mortality in young adults with end-stage renal disease: an analysis of the US Renal Data System. JAMA Cardiol. https://doi.org/10.1001/jamacardio.2019.0375 (2019).

    Article  PubMed  Google Scholar 

  6. Villar, E. et al. Effect of age, gender, and diabetes on excess death in end-stage renal failure. J. Am. Soc. Nephrol. 18, 2125–2134 (2007).

    Article  Google Scholar 

  7. USRDS Data Coordinating Center. 2018 annual data report. US Renal Data System https://www.usrds.org/adr.aspx (2018).

  8. Kendrick, J. & Chonchol, M. B. Nontraditional risk factors for cardiovascular disease in patients with chronic kidney disease. Nat. Clin. Pract. Nephrol. 4, 672–681 (2008).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. University of California San Francisco, Department of Medicine and Pediatrics, Divisions of Nephrology and Pediatric Nephrology, San Francisco, CA, USA

    Elaine Ku

  2. Cincinnati Children’s Hospital Medical Center, Division of Nephrology and Hypertension, Cincinnati, OH, USA

    Mark M. Mitsnefes

Authors
  1. Elaine Ku
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Mark M. Mitsnefes
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Mark M. Mitsnefes.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Ku, E., Mitsnefes, M.M. Cardiovascular disease in young adults with incident ESRD. Nat Rev Nephrol 15, 390–391 (2019). https://doi.org/10.1038/s41581-019-0154-3

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41581-019-0154-3

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing