MICROBIOME

Gut microbial short-chain fatty acids and the risk of diabetes

A new study used genome-wide association data and Mendelian randomization to investigate associations between the gut microbiome and metabolic traits. The researchers demonstrate that host genetic variants influence levels of the short-chain fatty acids butyrate and propionate in the gut, which in turn modulate host glycaemic metabolism.

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Fig. 1: Host genetics, gut microbiota SCFAs and risk of diabetes.

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Acknowledgements

W.L.L. is funded by American Heart Association grant 17IRG33410803 and National Institutes of Health–National Institute of Neurological Disorders and Stroke grant R01 NS20989.

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Correspondence to Wei Ling Lau or Nosratola D. Vaziri.

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The authors declare no competing interests.

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