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Modelling diabetic vasculopathy with human vessel organoids

Nature Reviews Nephrologyvolume 15pages258260 (2019) | Download Citation

A new study reports that human blood vessel organoids can be generated through the directed differentiation of human pluripotent stem cells. Use of these blood vessel organoids to model diabetic vasculopathy led to the identification of a new potential therapeutic target, suggesting that this system could have translational value for studies of diabetes complications.

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Author information


  1. Renal Division, Brigham and Women’s Hospital, Boston, MA, USA

    • Ryuji Morizane
  2. Department of Medicine, Harvard Medical School, Boston, MA, USA

    • Ryuji Morizane
  3. Harvard Stem Cell Institute, Cambridge, MA, USA

    • Ryuji Morizane
  4. Wyss Institute for Biologically Inspired Engineering, Harvard University, Cambridge, MA, USA

    • Ryuji Morizane


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Competing interests

R.M. is a co-inventor on patents (PCT/US16/52350) relating to organoid technologies that are assigned to Partners HealthCare.

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Correspondence to Ryuji Morizane.

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