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ORGANOIDS

Modelling diabetic vasculopathy with human vessel organoids

Nature Reviews Nephrology volume 15, pages 258–260 (2019)Cite this article

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A new study reports that human blood vessel organoids can be generated through the directed differentiation of human pluripotent stem cells. Use of these blood vessel organoids to model diabetic vasculopathy led to the identification of a new potential therapeutic target, suggesting that this system could have translational value for studies of diabetes complications.

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Fig. 1: Protocol for the generation of human blood vessel organoids to model diabetic vasculopathy.

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Authors and Affiliations

  1. Renal Division, Brigham and Women’s Hospital, Boston, MA, USA

    Ryuji Morizane

  2. Department of Medicine, Harvard Medical School, Boston, MA, USA

    Ryuji Morizane

  3. Harvard Stem Cell Institute, Cambridge, MA, USA

    Ryuji Morizane

  4. Wyss Institute for Biologically Inspired Engineering, Harvard University, Cambridge, MA, USA

    Ryuji Morizane

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  1. Ryuji Morizane
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Correspondence to Ryuji Morizane.

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Competing interests

R.M. is a co-inventor on patents (PCT/US16/52350) relating to organoid technologies that are assigned to Partners HealthCare.

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Morizane, R. Modelling diabetic vasculopathy with human vessel organoids. Nat Rev Nephrol 15, 258–260 (2019). https://doi.org/10.1038/s41581-019-0125-8

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