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DNA methylation links intrauterine stress with abnormal nephrogenesis

Nature Reviews Nephrologyvolume 15pages196197 (2019) | Download Citation

Scientists have long wondered how maternal diabetes, malnutrition and placental dysfunction impair fetal nephrogenesis. A new study discovered a link between prenatal metabolic stress and nephron deficit via dysregulation of DNA methylation — an epigenetic mechanism that is essential for the renewal and differentiation of nephron progenitors.

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Acknowledgements

The author is funded by grant RO1 DK 114050 from the US National Institutes of Health.

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Affiliations

  1. Department of Pediatrics, Tulane University School of Medicine, New Orleans, LA, USA

    • Samir S. El-Dahr

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  1. Search for Samir S. El-Dahr in:

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The author declares no competing interests.

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Correspondence to Samir S. El-Dahr.

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https://doi.org/10.1038/s41581-019-0114-y

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