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Sodium transport in diabetes: two sides to the coin

Nature Reviews Nephrology (2018) | Download Citation

New findings implicate sodium transport in α-cell secretory dysfunction, leading to impaired counter-regulatory responses in diabetes. However, these findings also raise important questions about the tissue-specific roles of sodium transport and suggest that inhibitors of sodium transport may have potentially divergent roles in the pancreas, kidney and heart.

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Author information


  1. Division of Endocrinology and Metabolism, Department of Medicine, Sunnybrook Health Sciences Centre, Sunnybrook Research Institute, University of Toronto, Toronto, Ontario, Canada

    • Julie A. Lovshin
  2. Division of Nephrology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada

    • David Z. Cherney


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Competing interests

J.A.L. has received consulting fees and/or speaking honorarium from Boehringer Ingelheim, Prometic, Intarcia Therapeutics, Inc., Novo Nordisk, Eli Lilly & Co, Merck and AstraZeneca, and has received operating grant support from Merck and Sanofi. D.Z.C. has received consulting fees and/or speaking honorarium from Janssen, Boehringer Ingelheim-Eli, Lilly, AstraZeneca, Merck, Sanofi and Prometic, and has received operating funds from Janssen, Boehringer Ingelheim-Eli, Lilly, AstraZeneca and Merck.

Corresponding author

Correspondence to Julie A. Lovshin.

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