Numerous exciting studies that advanced our understanding of immune-mediated kidney disease were published in 2018. Whereas most of these studies analysed the role of pro-inflammatory mediators, several novel anti-inflammatory mechanisms were discovered that involve immune cells and mediators with previously unrecognized protective roles in renal disease.
Glomerular podocytes reside in an immune-privileged site and so are protected from cytotoxic T lymphocytes (CTLs); disruption of Bowman’s capsule during glomerulonephritis renders podocytes susceptible to killing by CTLs2.
Fibrocytes are important producers of collagen for the repair of mechanical kidney injury, but can also contribute to renal fibrosis during chronic inflammation6.
Renal resident type 2 innate lymphoid cells (ILC2s) exert a potent protective function in renal ischaemia–reperfusion injury by producing amphiregulin and inducing M2 polarization8.
The pro-inflammatory cytokine macrophage migration inhibitory factor (MIF) also has anti-inflammatory effects that protect kidney tubular cells after ischaemia–reperfusion injury and rhabdomyolysis9.
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The authors’ work was supported by the Deutsche Forschungsgemeinschaft grants SFB1192 (C.K. and C.M.S.) and SFBTR57 (C.K.), and by the European Union’s Horizon 2020 research and innovation programme, grant no. 668036- RELENT (C.K.).
The authors declare no competing interests.
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Kurts, C., Meyer-Schwesinger, C. Protecting the kidney against autoimmunity and inflammation. Nat Rev Nephrol 15, 66–68 (2019). https://doi.org/10.1038/s41581-018-0097-0
Kidney International (2021)