Discoveries in 2018 using single-cell sequencing and gene-editing technologies have revealed their transformative potential for the investigation of kidney physiology and disease. Their promise is matched by the speed of their evolution.
Advances in CRISPR–Cas9 gene editing have facilitated the development of new approaches to activate the expression of protective gene programmes in kidney disease models, providing an encouraging proof of principle for this therapeutic approach8,10.
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The authors declare no competing interests.
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Wilson, P.C., Humphreys, B.D. Single-cell genomics and gene editing: implications for nephrology. Nat Rev Nephrol 15, 63–64 (2019). https://doi.org/10.1038/s41581-018-0094-3
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