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Albuminuria as a cause of hypertension

Nature Reviews Nephrology (2018) | Download Citation

A genetic study using a Mendelian randomization approach provides evidence that albuminuria — as well as being the result of hypertension — might also cause hypertension and cardiometabolic disease. We suggest that a mechanism behind these findings could involve sodium retention by urinary protein-induced activation of the epithelial sodium channel in the distal tubule.

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Author information


  1. Department of Nephrology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands

    • Ron T. Gansevoort
  2. Department of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands

    • Harold Snieder


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Competing interests

The authors declare no competing interests.

Corresponding authors

Correspondence to Ron T. Gansevoort or Harold Snieder.

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