Autosomal dominant PKD gets an atomic map

The polycystin complex structure has been solved at near-atomic resolution. Its surprising architecture provides new insights into the transient receptor potential (TRP) family of cation channels and the pathogenesis of autosomal dominant polycystic kidney disease. This discovery should have a transformative impact on the development of treatment strategies to cure the disease.

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Fig. 1: A top-down view of polycystin complexes.


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The author is supported by grants from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), including to the Baltimore Polycystic Kidney Disease (PKD) Research and Clinical Core Center.

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Correspondence to Paul A. Welling.

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Welling, P.A. Autosomal dominant PKD gets an atomic map. Nat Rev Nephrol 14, 725–726 (2018). https://doi.org/10.1038/s41581-018-0066-7

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