Three reports from the TRACERx Renal study delineate the precise origin and evolution of clear cell renal cell carcinoma in minute detail. The insights gained from these studies might provide improved disease prognostics and identify novel therapeutic targets.
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Acknowledgements
The authors’ work is supported by the Intramural Research Program of the US National Institutes of Health (NIH), National Cancer Institute, Center for Cancer Research.
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Ricketts, C.J., Linehan, W.M. The origin, evolution and route to metastasis of clear cell RCC. Nat Rev Nephrol 14, 538–540 (2018). https://doi.org/10.1038/s41581-018-0031-5
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DOI: https://doi.org/10.1038/s41581-018-0031-5
