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Rethinking progression of CKD as a process of punctuated equilibrium

Nature Reviews Nephrology volume 14, pages 411–412 (2018)Cite this article

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Although most nephrologists spend their days managing patients with acute and chronic kidney disease (CKD), it is useful to occasionally consider the landscape of our current treatment approach. Here, we present the hypothesis that the major mechanisms that drive CKD are changing and will necessitate new approaches to manage this disease.

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Fig. 1: Patterns of CKD progression.

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Acknowledgements

Research conducted in the authors’ laboratories is funded by grants from FONACYT, Venezuela (FC-2005000283, to BR-I) and Asociación de Amigos del Riñón (to BR-I) and by the National Institutes of Health NIDDK Institute (1RO1DK109408-01A1 and R01 DK108859-01).

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Authors and Affiliations

  1. Division of Renal Diseases and Hypertension, University of Colorado Anschutz Medical Campus, Aurora, CO, USA

    Richard J. Johnson

  2. Nephrology Service Hospital Universitario, Universidad del Zulia, Instituto Venezolano de Investigaciones Científicas (IVIC-Zulia), Maracaibo, Venezuela

    Bernardo Rodriguez-Iturbe

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  1. Richard J. Johnson
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  2. Bernardo Rodriguez-Iturbe
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Correspondence to Richard J. Johnson.

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Competing interests

R.J.J. is on the Scientific Board of XORT Therapeutics, has patent and patent applications related to lowering uric acid or blocking fructose metabolism in the treatment of hypertension and metabolic disorders, and is a member of Colorado Research Partners, LLC, which is developing inhibitors of fructose metabolism. B.R.I. declares no competing interests.

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Johnson, R.J., Rodriguez-Iturbe, B. Rethinking progression of CKD as a process of punctuated equilibrium. Nat Rev Nephrol 14, 411–412 (2018). https://doi.org/10.1038/s41581-018-0016-4

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