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Cellular recording devices imprint the history of the cell

Nature Reviews Nephrologyvolume 14pages477478 (2018) | Download Citation

Technologies such as proteomics provide a snapshot of a specific cellular state but are unable to directly record successive signalling events. Two new CRISPR-mediated analogue multi-event recording apparatus (CAMERA) systems enable sequential recording of endogenous and exogenous signalling events by targeted DNA modifications, thereby allowing systematic interrogation of different cellular states.

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Author information


  1. Division of Nephrology, Department of Medicine, Columbia University Medical Center, Russ Berrie Pavilion, New York, NY, USA

    • Nicholas J. Steers
    •  & Ali G. Gharavi


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Competing interests

The authors declare no competing interests.

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Correspondence to Ali G. Gharavi.

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