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Abnormal saline and the history of intravenous fluids

Nature Reviews Nephrologyvolume 14pages358360 (2018) | Download Citation

Two new clinical trials together involving nearly 30,000 patients support previous observational evidence that the most common solution used for intravenous fluid therapy in the world is associated with kidney damage. Both trials found that 0.9% saline was inferior to solutions with more physiological chloride concentrations and resulted in greater rates of major adverse kidney events.

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Author information


  1. Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA, USA

    • John A. Kellum


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Competing interests

J.A.K. has received consulting fees and grant support from Baxter for unrelated research. J.A.K. is also a co-investigator for the Balanced Solution versus Saline in Intensive Care Study (BaSICS) (NCT02875873).

Corresponding author

Correspondence to John A. Kellum.

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