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  Heart failure

Implantable cardioverter defibrillators in chronic kidney disease

A recent observational study reports that implantable cardioverter defibrillators were not associated with improved survival in patients with heart failure, reduced left ventricular ejection fraction and chronic kidney disease. Further studies are needed to identify which of these high-risk patients are most likely to benefit from this potentially life-saving therapy.

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Acknowledgements

The authors wish to acknowledge helpful discussions with D. M. Charytan (Brigham and Women’s Hospital, Boston, USA) and B. Claggett (Brigham and Women’s Hospital, Boston, USA) regarding this manuscript.

Author information

Affiliations

  1. Renal Division, Department of Medicine, Brigham and Women’s Hospital, Boston, MA, USA

    • Finnian R. Mc Causland
  2. Harvard Medical School, Boston, MA, USA

    • Finnian R. Mc Causland
    •  & Marc A. Pfeffer
  3. Cardiology Division, Department of Medicine, Brigham and Women’s Hospital, Boston, MA, USA

    • Marc A. Pfeffer

Authors

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Competing interests

M.A.P. receives research support from Novartis and serves as a consultant for AstraZeneca, Bayer, Boehringer Ingelheim, DalCor, Genzyme, Gilead, GlaxoSmithKline, Janssen, Lilly, Novartis, Novo Nordisk, Relypsa, Sanofi, Teva and Thrasos. He also has stock options for DalCor. F.R.M. reports no competing interests.

Corresponding author

Correspondence to Marc A. Pfeffer.