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Is endocytosis by caveolae dependent on dynamin?

The large GTPase dynamin has a crucial role in endocytosis, working at the neck of clathrin-coated pits to drive vesicular scission. Until recently, dynamin was believed to regulate endocytosis through caveolae in a similar fashion. However, recent work calls for a serious reassessment of the role of dynamin in endocytosis by caveolae.

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Fig. 1: Comparison of the proposed roles of dynamin in clathrin-coated pits and caveolae.


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R.G.P. is funded by an ARC Laureate Fellowship. We thank S. Schmid for excellent discussions. J.W.T. is supported by the Intramural Research Program of the National Heart, Lung, and Blood Institute, National Institutes of Health, USA.

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Correspondence to Robert G. Parton, Justin W. Taraska or Richard Lundmark.

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Nature Reviews Molecular Cell Biology thanks Aurelien Roux for his contribution to the peer review of this work.

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Parton, R.G., Taraska, J.W. & Lundmark, R. Is endocytosis by caveolae dependent on dynamin?. Nat Rev Mol Cell Biol (2024).

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