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New frontiers in quality control: the case of GPI-anchored proteins

The biosynthesis and trafficking of glycosylphosphatidylinositol-anchored proteins (GPI-APs), many of enormous clinical importance, are complex multistep processes involving dozens of dedicated factors. Recent work indicates that the quality control of GPI-APs is similarly complex, varying substantially between different eukaryotic species and relying on several previously unknown cellular mechanisms.

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L.L. and V.G. are supported by Agencia Estatal de Investigación (PID2019-108564GB-I00 and MCIN/AEI/10.13039/501100011033). L.L. is a fellow of the European Regional Development Fund from the Junta de Andalucía. R.S.H. is supported by the Medical Research Council, part of UK Research and Innovation (grant number MC_UP_A022_1007).

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Correspondence to Leticia Lemus or Veit Goder.

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Nature Reviews Molecular Cell Biology thanks the anonymous, reviewer(s) for their contribution to the peer review of this work.

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Lemus, L., Hegde, R.S. & Goder, V. New frontiers in quality control: the case of GPI-anchored proteins. Nat Rev Mol Cell Biol 24, 599–600 (2023).

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