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Cell senescence

Senescent fibroblasts support lung repair

Nature Reviews Molecular Cell Biology volume 23, page 775 (2022)Cite this article

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The emergence of senescent cells is generally associated with ageing and decline of tissue regeneration. Reyes et al. now show that fibroblasts with cellular senescence properties are present in healthy epithelial tissues and — by upregulating the senescence associated secretory phenotype (SASP) — they support stem-cell function and tissue repair.

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References

Original article

  • Reyes, N. S. et al. Sentinel p16INK4a+ cells in the basement membrane form a reparative niche in the lung. Science 378, 192–201 (2022)

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Related article

  • di Micco, R. et al. Cellular senescence in ageing: from mechanisms to therapeutic opportunities. Nat. Rev. Mol. Cell Biol. 22, 75–95 (2021)

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  1. Nature Reviews Molecular Cell Biology http://www.nature.com/nrm/

    Paulina Strzyz

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  1. Paulina Strzyz
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Correspondence to Paulina Strzyz.

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Strzyz, P. Senescent fibroblasts support lung repair. Nat Rev Mol Cell Biol 23, 775 (2022). https://doi.org/10.1038/s41580-022-00559-7

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  • DOI: https://doi.org/10.1038/s41580-022-00559-7

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