Cellular protrusions are highly dynamic structures that facilitate cell–cell communication and are increasingly recognised for their roles in the shedding of bioactive extracellular vesicles (EVs). The intrinsic and extrinsic mechanisms that govern the shedding of EVs from cellular protrusions and their potential physiological roles are beginning to emerge.
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We thank N. Gov at Weizmann Institute, R. Sorkin at Tel Aviv University, and M. Kozlov at Tel Aviv University and lab members for insightful discussions. We sincerely apologize to the many authors whom we could not cite due to space limitations. This work was supported by the Fondation pour la Recherche Medicale (FRM 2020-2023), Institut Curie and the Centre National de la Recherche Scientifique (CNRS) to G.A. and G.R., Japan Society for Promotion of Science (KAKENHI, JP 20H03252, JP20KK0341, JP21H05047) to SS., Japan Society for Promotion of Science (JP20K06625) to T.N., and Japan Science and Technology cooperation CREST (JPMJCR1863) to S.S.
The authors declare no competing interests.
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D’Angelo, G., Raposo, G., Nishimura, T. et al. Protrusion-derived vesicles: new subtype of EVs?. Nat Rev Mol Cell Biol 24, 81–82 (2023). https://doi.org/10.1038/s41580-022-00555-x