A long-standing paradigm in molecular biology assumes a direct relationship between increases in mRNA levels and the abundance of the proteins they encode. Here, we challenge our understanding of the complex relationship between changes in the skeletal muscle transcriptome and proteome in response to repeated muscle contractions.
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Our work is, in part, funded by an Australian Research Council grant (DP160102176).
The authors declare no competing interests.
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Nature Reviews Molecular Cell Biology thanks the anonymous reviewers for their contribution to the peer review of this work.
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Bishop, D.J., Hawley, J.A. Reassessing the relationship between mRNA levels and protein abundance in exercised skeletal muscles. Nat Rev Mol Cell Biol 23, 773–774 (2022). https://doi.org/10.1038/s41580-022-00541-3