Regulation of intercellular small RNA (sRNA)-mediated gene silencing in plants is commonly ascribed to hypothetical mechanisms involving movement channels. In this commentary, I present a complementary, perhaps counter-intuitive view, in which sRNA movement is also crucially regulated by the cell-autonomous silencing machinery found in silencing-emitting, traversed and recipient cells.
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The author declares no competing interests.
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Voinnet, O. Revisiting small RNA movement in plants. Nat Rev Mol Cell Biol 23, 163–164 (2022). https://doi.org/10.1038/s41580-022-00455-0