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New guidelines for embryo and stem cell research

This year the International Society for Stem Cell Research (ISSCR) updated its Guidelines for Stem Cell Research and Clinical Translation. Here we discuss some key changes to the 2016 guidelines, and the need for such changes in light of advances in research using models of human development.

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  1. Rivron, N. C. et al. Blastocyst-like structures generated solely from stem cells. Nature 557, 106–111 (2018).

    Article  CAS  Google Scholar 

  2. Moris, N. et al. An in vitro model of early anteroposterior organization during human development. Nature 582, 410–415 (2020).

    Article  CAS  Google Scholar 

  3. Lancaster, M. et al. Cerebral organoids model human brain development and microcephaly. Nature 501, 373–379 (2013).

    Article  CAS  Google Scholar 

  4. Sasaki, K. et al. Robust in vitro induction of human germ cell fate from pluripotent stem cells. Cell Stem Cell 17, 178–94 (2015).

    Article  CAS  Google Scholar 

  5. Lovell-Badge, R. et al. ISSCR Guidelines for Stem Cell Research and Clinical Translation: the 2021 update. Stem Cell Reports 16, 1398–1408 (2021).

    Article  Google Scholar 

  6. Deglincerti, A. et al. Self-organization of the in vitro attached human embryo. Nature 533, 251–254 (2016).

    Article  CAS  Google Scholar 

  7. Clark, A. T. et al. Human embryo research, stem cell-derived embryo models and in vitro gametogenesis: Considerations leading to the revised ISSCR guidelines. Stem Cell Reports 16, 1416–1424 (2021).

    Article  Google Scholar 

  8. Reardon, S. Can lab-grown brains become conscious? Nature 586, 658–661 (2020).

    Article  CAS  Google Scholar 

  9. Hyun, I. et al. ISSCR guidelines for the transfer of human pluripotent stem cells and their direct derivatives into animal hosts. Stem Cell Reports 16, 1409–1415 (2021).

    Article  Google Scholar 

  10. Zhang, J. et al. First live birth using human oocytes reconstituted by spindle nuclear transfer for mitochondrial DNA mutation causing Leigh syndrome. Fertil. Steril. 106, e375–e376 (2016).

    Article  Google Scholar 

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We thank Robin Lovell-Badge, chair of the ISSCR Guidelines committee, for comments on the manuscript draft.

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Correspondence to Christine Mummery.

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Competing interests

C.L.M. was President of ISSCR 2020-2021. E.A. is Director of Policy at ISSCR.

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Human genome editing: a framework for governance:

International Commission on the Clinical Use of Human Germline Genome Editing:

ISSCR Guidelines for Stem Cell Research and Clinical Translation (2021):

ISSCR Guidelines for Stem Cell Research and Clinical Translation (2016):

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Mummery, C., Anthony, E. New guidelines for embryo and stem cell research. Nat Rev Mol Cell Biol 22, 773–774 (2021).

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