This year the International Society for Stem Cell Research (ISSCR) updated its Guidelines for Stem Cell Research and Clinical Translation. Here we discuss some key changes to the 2016 guidelines, and the need for such changes in light of advances in research using models of human development.
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We thank Robin Lovell-Badge, chair of the ISSCR Guidelines committee, for comments on the manuscript draft.
C.L.M. was President of ISSCR 2020-2021. E.A. is Director of Policy at ISSCR.
Human genome editing: a framework for governance: https://www.who.int/publications/i/item/9789240030060
International Commission on the Clinical Use of Human Germline Genome Editing: https://www.nationalacademies.org/our-work/international-commission-on-the-clinical-use-of-human-germline-genome-editing
ISSCR Guidelines for Stem Cell Research and Clinical Translation (2021): https://www.isscr.org/docs/default-source/all-isscr-guidelines/2021-guidelines/isscr-guidelines-for-stem-cell-research-and-clinical-translation-2021.pdf?sfvrsn=979d58b1_4
ISSCR Guidelines for Stem Cell Research and Clinical Translation (2016): https://www.isscr.org/docs/default-source/all-isscr-guidelines/guidelines-2016/isscr-guidelines-for-stem-cell-research-and-clinical-translationd67119731dff6ddbb37cff0000940c19.pdf?sfvrsn=4
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Mummery, C., Anthony, E. New guidelines for embryo and stem cell research. Nat Rev Mol Cell Biol 22, 773–774 (2021). https://doi.org/10.1038/s41580-021-00429-8