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The role of ordered cooperative assembly in biomolecular condensates

Biomolecular condensates, regardless of whether they exhibit liquid-like properties, are in many cases not fully amorphous, but instead exhibit partial degrees of local structure and order. Here, we discuss how ordered interactions may underlie the cooperative assembly and cellular function of a wide variety of partially ordered macromolecular assemblies.

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We thank W. I. Weis for his insightful comments on the text, and A. J. Spakowitz and V. T. Vachharajani for insightful discussions. We sincerely apologize to the many authors who we could not cite to due space limitations. This work was supported by 1R35GM130332 and a Howard Hughes Medical Institute Faculty Fellow Award (A.R.D.), a Stanford Bio-X Fellowship (E.K.), grants K124670 and K131702 from the Hungarian Scientific Research Fund (OTKA) and a Spearhead grant (SRP51) from the Vrije Universiteit Brussel (P.T.).

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Correspondence to Alexander R. Dunn.

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Korkmazhan, E., Tompa, P. & Dunn, A.R. The role of ordered cooperative assembly in biomolecular condensates. Nat Rev Mol Cell Biol 22, 647–648 (2021).

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